50 Years Ago in The Journal of Pediatrics


Lees MH. Cyanosis of the newborn infant. Recognition and clinical evaluation. J Pediatr 1970;3:484-98.

It has been almost 100 years since Lundsgaard et al described that clinical cyanosis is dependent on the absolute concentration of reduced hemoglobin in the blood, as well as on the difference between central and peripheral cyanosis. It was recognized that organs such as the tongue with a high blood flow and a small arteriovenous oxygen difference might not appear cyanotic as readily as organs with a low blood flow and a large arteriovenous oxygen difference, such as skin of cool hands and feet. This was the background of the concept of central and peripheral cyanosis.

  • Lundsgaard C.
  • Van Slyke D.
  • Abbott M.E.