Relationships Between Right Amygdala-Medial Prefrontal Cortex (mPFC) Functional Connectivity, Right Amygdala Reactivity, and Negative Affect
Note: (A) Scatter plot illustrating the relationship between right amygdala−mPFC functional connectivity and right amygdala reactivity to facial expressions of emotion and parent-reported negative affect (see Methods for greater detail). (B) Results of statistical mediation model in which amygdala−mPFC functional connectivity was found to mediate the relationship between amygdala reactivity and child negative affect. The association between right amygdala reactivity and right amygdala−mPFC functional connectivity, and between right amygdala−mPFC functional connectivity and Negativity, report unstandardized (top value) and standardized (bottom value) β values after controlling for sex, age, and maternal depression. Brain images in the center of the figure illustrate the mPFC region used in these analyses.