Brain wiring could be behind learning difficulties, say experts

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Scientists say current system for labelling children with difficulties is ‘too simple’Learning difficulties are not linked to differences in particular brain regions, but in how the brain is wired, research suggests.According to figures from the Department for Education, 14.9% of all pupils in England – about 1.3 million children – had special educational needs in January 2019, with 271,200 having difficulties that required support beyond typical special needs provision. Dyslexia, attention deficit hyperactivity disorder (ADHD), autism and dyspraxia are among conditions linked to learning dif ficulties.Continue reading…

Source: Guardian Unlimited ScienceCategory: Science Authors: Tags: Neuroscience Dyslexia Attention deficit hyperactivity disorder Autism Health Education Society Schools Source Type: news

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Conclusions: Since the presence of behavioural comorbidities influences individualised treatment approaches, it is likely that a more precise characterisation of TS phenotypes, including cognitive aspects, will result in improved levels of care for patients with tic disorders.
PMID: 32372718 [PubMed – as supplied by publisher]

CONCLUSIONS: Oral 600mg ALA twice daily treatment for DPN over 6 months is effective, safe and tolerable.
PMID: 32370731 [PubMed – as supplied by publisher]

Authors: Declerq J, Vanhove W, Benis S, Hollevoet N
Abstract
The aim of the study was to find out if ulnar shortening is effective to treat ulnar wrist pain and which factors influence outcome. Thirty-seven patients were evalua- ted with a mean follow-up of 4.5 years. Thirty patients (81%) would undergo the same operation again although 21 (57%) had residual ulnar wrist pain. Mean disabilities of arm, shoulder and hand (DASH) score was 22 and mean patient rated wrist evaluation score (PRWE) was 33. DASH and PRWE scores were better in smokers, in patients operated on the non- dominant side and when follow-up was lon…

Authors: Kraal T, Van der Meer O, Van den Borne M, Koenraadt K, Eygendaal D, Boer R
Abstract
ABBREVIATIONS: MUA, manipulation under anesthesia ; FS, frozen shoulder ; SPADI, Shoulder Pain and Disability Score ; OSS, Oxford Shoulder Score ; NPRS, Numeric Paind Rating Scale. Manipulation under anesthesia is a well-established, but controversial, treatment for frozen shoulders. We will evaluate our results of manipulation and physiotherapy in stage two frozen shoulders. Questionnaires were sent to 65 patients with stage 2 frozen shoulders, treated with manipulation under anaesthesia between January 2012 and January 20…

Publication date: June 2020Source: Molecular Genetics and Metabolism Reports, Volume 23Author(s): Marina Macchiaiolo, Paola Sabrina Buonuomo, Gerarda Mastrogiorgio, Matteo Bordi, Beatrice Testa, Gerrit Weber, Emanuele Bellacchio, Marco Tartaglia, Francesco Cecconi, Andrea Bartuli

Authors: Esmael A, Elsherif M, Abdelsalam M, Sabry D, Mamdouh M, Belal T
Abstract
Objectives: The purpose of this research is to predict the cognitive impairment and to determine its correlation with retinal thickness, mainly (RFNL and GCIPL) in cases of multiple sclerosis.Methods: 60 multiple sclerosis patients and 30 age and sex-matched healthy controls were included in this study. Cognitive functions were evaluated in all study participants by the Montreal Cognitive Assessment (MoCA). OCT imaging was done to determine the thickness. The correlation between the cognitive domains of MoCA and the thickness of the r…

Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare and disabling disorder of fibroblast growth factor 23 (FGF23) deficiency or resistance. The disorder is manifest by hyperphosphatemia, inappropriately increased tubular reabsorption of phosphate and 1,25-dihydroxy-Vitamin D, and ectopic calcifications. HFTC has been associated with autosomal recessive pathogenic variants in: (1) the gene encoding FGF23; (2) GALNT3, which encodes a protein responsible for FGF23 glycosylation; and (3) KL, the gene encoding KLOTHO, a critical co-receptor for FGF23 signaling. An acquired autoimmune form of hyperphosphatemic tumoral…

Much of the signaling that passes between cells is carried in extracellular vesicles, small membrane-wrapped packages of molecules. There are numerous classes of such vesicle, varying in size, such as microvesicles and exosomes. The study of vesicles has expanded considerably in recent years, as they are much easier to work with than cells, and their use is applicable to many therapeutic goals.



For example, most cell therapies presently in use produce their benefits via the signaling that is generated by transplanted cells in the short period of time before they die. Cells can largely be replaced with extracellular …

Source: Fight Aging!Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs

Sleep difficulties are more prevalent in 6- to 12-month-olds who later develop autism spectrum disorder (ASD) compared with those who do not, reports astudy published today inAJP in Advance. The study also found that these early sleep problems were associated with subsequent altered development in the brain ’s hippocampus.“The hippocampus is critical for learning and memory, and changes in the size of the hippocampus have been associated with poor sleep in adults and older children,” stated lead author Kate MacDuffie, Ph.D., of the University of Washington Autism Center in a press release. “However,…

Source: Psychiatr NewsCategory: Psychiatry Tags: ajp in advance ASD autism familial risk infants Kate MacDuffie neurodevelopment Source Type: research

In conclusion, none of us planned for this terrible virus to circle the globe. And none of us could anticipate how dangerous maintaining close social contact could become. We, like most, are simply making the best of a horrific situation.
COVID-19 is bad, but it’s much worse if you’re autistic. You are simply one step more removed from people, and this, although significantly detrimental, can be compensated for with a little love and creativity.

Source: World of PsychologyCategory: Psychiatry & Psychology Authors: Tags: Aspergers Autism Children and Teens Parenting Personal Autism Spectrum Autistic Children coronavirus COVID-19 pandemic Source Type: blogs

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