Changes in Routine Pediatric Practice in Light of COVID-19

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Although peer-reviewed reports and commentaries may not provide an exhaustive epidemiological and clinical overview on how children respond to COVID-19, they provide a useful early look. Differences were observed between adults and children, which may have implications for the management of this disease in the younger population.

Information on morbidity and mortality by COVID-19 were first documented in adults.4x4)Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y. et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020 Mar 26;
382: 1199–1207
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The reasons for the relatively milder viral phenotype in children remain elusive. Several factors were proposed as causative, including differences in ACE2 expression in children, simultaneous infection (co-infection) of competing viruses in children, and the age related immature immune systems.15x15)Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, Tong S. Epidemiological Characteristics of 2143 Pediatric Patients with 2019 Coronavirus Disease in China. Pediatrics, 2020. https://pediatrics.aappublications.org/content/pediatrics/early/2020/03/16/peds.2020-0702.full.pdf (Accessed, 3 May, 2020)
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