BACKGROUND: The study aimed to investigate if the behaviours suggestive of ADHD were more frequent in a population of children attending the Emergency Department (ED) for injuries, rather than for other causes.
METHODS: A cross-sectional study was carr…
Publication date: Available online 31 May 2020Source: Academic PediatricsAuthor(s): Jessica E. Rast, Kristy A. Anderson, Anne M. Roux, Paul T. Shattuck
The advent and application of high-throughput sequencing is revolutionizing our understanding of the molecular neurobiology of diverse psychiatric disorders. Whole-genome sequencing, which targets the coding regions of the genome, and whole-exome sequencing are being applied to study multiple psychiatric disorders, including autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder, schizophrenia, and Tourette ’s disorder, among others [(1–3); https://schema.broadinstitute.org]. These studies have demonstrated a role for ultrarare, deleterious, frequently de novo variation in each disorder, and h…
Tourette syndrome (TS), also known as Tourette ’s disorder, is a neurodevelopmental disorder with onset in early childhood characterized by multiple motor tics and at least one vocal tic that have been present for longer than 1 year. TS is a model neuropsychiatric disorder, in that the vast majority of affected individuals, whether ascertained in clinical or community settings, experience at least one co-occurring psychiatric disorder, such as attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, and/or mood, anxiety, and specific learning disorders (1).
Publication date: Available online 26 May 2020Source: NeuroImage: ClinicalAuthor(s): Sheut-Ling Lam, Marion Criaud, Analucia Alegria, Gareth J. Barker, Vincent Giampietro, Katya Rubia
In this issue of the Journal, Blader et al.1 report the results of a double-blind randomized controlled trial (RCT) aimed at assessing the comparative efficacy and tolerability of adjunctive risperidone (RISP), valproex sodium (DVPX) or placebo for aggressive behaviors in children (aged 6-12) with attention-deficit/hyperactivity disorder (ADHD) and comorbid oppositional defiant disorder (ODD), or conduct disorder (CD), as well as a prior history of psychostimulant treatment. Participants with aggressive symptoms persisting after an open-label optimization of psychostimulant medication entered the 8-week randomized phase.
ConclusionsIn addition to confirming the role of MDD, we demonstrate that ADHD and schizophrenia likely play a role in the aetiology of self-harm using multivariate genetic designs for causal inference. Among the many individual risk factors we simultaneously considered, our findings suggest that systematic detection and treatment of core psychiatric symptoms, including psychotic and impulsivity symptoms, may be beneficial among people at risk for self-harm.
Authors: Sagiadinou M, Plerou A
Neurofeedback video games respond to electrical brain signals instead to a mouse, joystick, or game controller input. These games embody the concept of improving physiological functioning by rewarding specific healthy body signals with success at playing a video game. In this paper, a threefold framework in reference to attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD) treatment blending with neurofeedback techniques and video game implementation is presented. In particular, the specifications of a neurofeedback-based video game for childre…
Conclusions: Although these data suggest ADHD symptom and EF deficit improvement following lisdexamfetamine are interdependent, it is advantageous to use measures like the BRIEF-A to assess stimulant effects on the wide range of EF deficits associated with ADHD that are not captured by the ADHD-RS-AP alone.
Trial Registration: Data used in this secondary analysis came from ClinicalTrials.gov identifier: NCT01101022.
PMID: 32470230 [PubMed – as supplied by publisher]
This study examined the levels of agreement between the reports of 207 adolescents with attention-deficit/hyperactivity disorder (ADHD) and their parents regarding the adolescents’ callous–unemotional (CU) traits and investigated the factors influencing adolescent–parent agreement. Adolescent–parent agreement about CU traits in three dimensions according to the Chinese version of the Inventory of Callous and Unemotional Traits was examined. The influence of demographic characteristics, comorbid conduct disorder (CD), oppositional defiant disorder (ODD), and ADHD symptoms on adolescen…
AbstractPolypharmacy is common in the treatment of attention-deficit hyperactivity disorder (ADHD). However, the use of multiple drugs increases the risk of pharmacokinetic drug –drug interactions (DDIs) and subsequent adverse safety outcomes. Clinically relevant pharmacokinetic DDIs can be prevented by adjusting the dose of the ADHD drug or, if possible, by using an alternative drug that would not have a pharmacokinetic effect on the ADHD drug.