Estimating individual scores of inattention and impulsivity based on dynamic features of intrinsic connectivity network

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Inattention and impulsivity are the two most important indices for evaluations of ADHD. Currently, inattention and impulsivity were evaluated by clinical scales. The intelligent evaluation of the two indices using machine learning remains largely unexplore…

Source: SafetyLitCategory: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

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Publication date: Available online 4 May 2020Source: Biocybernetics and Biomedical EngineeringAuthor(s): Miray Altınkaynak, Nazan Dolu, Ayşegül Güven, Ferhat Pektaş, Sevgi Özmen, Esra Demirci, Meltem İzzetoğlu

OBJECTIVE: We evaluated processing-speed and shift-cost measures in adults with depression or ADHD and monitored the effects of treatment. We hypothesized that cognitive-speed and shift-cost measures might differentiate diagnostic groups. METHODS: …

Source: SafetyLitCategory: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Objective: To evaluate efficacy and safety of SPN-810 (extended-release molindone) in a Phase-2b, randomized, double-blind, placebo-controlled, dose-ranging study of children (6-12 years) with ADHD and persistent impulsive aggression (IA). Method…

Source: SafetyLitCategory: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Objectives: To evaluate the real-world effectiveness of ADHD medications on adverse driving outcomes in teenage drivers with ADHD. Method: We retrospectively followed 15- to 20-year-old ADHD patients with valid driver’s license to compare the…

Source: SafetyLitCategory: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Conclusions: The present study detected arithmetic difficulties in Brazilian children with ADHD and the effects of methylphenidate. Given this improvement in sensitivity, combining tests could be a promising alternative when working with limited samples.Resumo Objetivo: Comparar as formas de avaliar as habilidades aritm éticas em crianças brasileiras com TDAH, combinando três testes neuropsicológicos validados, e verificar se são sensíveis ao tratamento com metilfenidato. Métodos: Quarenta e duas crianças (9 ‒ 12 anos) participaram deste estudo: 20 eram crian &ccedil…

Contributors : Samantha Eck ; Song-Jun Xu ; Debra A BangasserSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusBackground: Stress exacerbates symptoms of schizophrenia and attention deficit hyperactivity disorder, which are characterized by impairments in sustained attention. Yet how stress regulates attention remains largely unexplored. Here we investigated whether a 6-day variable stressor (VS) altered sustained attention and the cholinergic attention system in male and female rats.Methods: Sustained attention was tested with the sustained attention task (SAT). Successful perform…

Source: GEO: Gene Expression OmnibusCategory: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research

ConclusionThe P3 amplitudes reflecting postdecisional processing and/or WM updating were sensitive to ADHD remission, as they might improve concurrently with ADHD symptoms. These results indicate that the N1, P2, and P3 components of WM processing might be potential biomarkers for different ADHD outcomes.

Conclusions: This study is the first to use the CIL-based LC-MS to profile ADHD plasma metabolites, and we identified nine novel metabolite biomarkers of ADHD.
PMID: 32351159 [PubMed – as supplied by publisher]

Source: The World Journal of Biological PsychiatryCategory: Psychiatry Authors: Tags: World J Biol Psychiatry Source Type: research

CONCLUSIONS: Our findings support impaired executive functions in youths with ASD. However, unaffected siblings were mostly unimpaired except in the areas of verbal and spatial working memory, which may be potential cognitive endophenotypes for ASD.
PMID: 32349803 [PubMed – as supplied by publisher]

Source: Psychological MedicineCategory: Psychiatry Authors: Tags: Psychol Med Source Type: research

Publication date: Available online 28 April 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Anatoly V. Skalny, Anna L. Mazaletskaya, Olga P. Ajsuvakova, Geir Bjørklund, Margarita G. Skalnaya, Svetlana V. Notova, Lyubov N. Chernova, Andrey A. Skalny, Tatiana I. Burtseva, Alexey A. Tinkov

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