Estimating individual scores of inattention and impulsivity based on dynamic features of intrinsic connectivity network

Inattention and impulsivity are the two most important indices for evaluations of ADHD. Currently, inattention and impulsivity were evaluated by clinical scales. The intelligent evaluation of the two indices using machine learning remains largely unexplore…

Publication date: Available online 4 May 2020Source: Biocybernetics and Biomedical EngineeringAuthor(s): Miray Altınkaynak, Nazan Dolu, Ayşegül Güven, Ferhat Pektaş, Sevgi Özmen, Esra Demirci, Meltem İzzetoğlu

OBJECTIVE: We evaluated processing-speed and shift-cost measures in adults with depression or ADHD and monitored the effects of treatment. We hypothesized that cognitive-speed and shift-cost measures might differentiate diagnostic groups. METHODS: …

Objective: To evaluate efficacy and safety of SPN-810 (extended-release molindone) in a Phase-2b, randomized, double-blind, placebo-controlled, dose-ranging study of children (6-12 years) with ADHD and persistent impulsive aggression (IA). Method…

Objectives: To evaluate the real-world effectiveness of ADHD medications on adverse driving outcomes in teenage drivers with ADHD. Method: We retrospectively followed 15- to 20-year-old ADHD patients with valid driver’s license to compare the…

Conclusions: The present study detected arithmetic difficulties in Brazilian children with ADHD and the effects of methylphenidate. Given this improvement in sensitivity, combining tests could be a promising alternative when working with limited samples.Resumo Objetivo: Comparar as formas de avaliar as habilidades aritm éticas em crianças brasileiras com TDAH, combinando três testes neuropsicológicos validados, e verificar se são sensíveis ao tratamento com metilfenidato. Métodos: Quarenta e duas crianças (9 ‒ 12 anos) participaram deste estudo: 20 eram crian &ccedil…

Contributors : Samantha Eck ; Song-Jun Xu ; Debra A BangasserSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusBackground: Stress exacerbates symptoms of schizophrenia and attention deficit hyperactivity disorder, which are characterized by impairments in sustained attention. Yet how stress regulates attention remains largely unexplored. Here we investigated whether a 6-day variable stressor (VS) altered sustained attention and the cholinergic attention system in male and female rats.Methods: Sustained attention was tested with the sustained attention task (SAT). Successful perform…

ConclusionThe P3 amplitudes reflecting postdecisional processing and/or WM updating were sensitive to ADHD remission, as they might improve concurrently with ADHD symptoms. These results indicate that the N1, P2, and P3 components of WM processing might be potential biomarkers for different ADHD outcomes.

Conclusions: This study is the first to use the CIL-based LC-MS to profile ADHD plasma metabolites, and we identified nine novel metabolite biomarkers of ADHD.
PMID: 32351159 [PubMed – as supplied by publisher]

CONCLUSIONS: Our findings support impaired executive functions in youths with ASD. However, unaffected siblings were mostly unimpaired except in the areas of verbal and spatial working memory, which may be potential cognitive endophenotypes for ASD.
PMID: 32349803 [PubMed – as supplied by publisher]

Publication date: Available online 28 April 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Anatoly V. Skalny, Anna L. Mazaletskaya, Olga P. Ajsuvakova, Geir Bjørklund, Margarita G. Skalnaya, Svetlana V. Notova, Lyubov N. Chernova, Andrey A. Skalny, Tatiana I. Burtseva, Alexey A. Tinkov