Functional, diffusion MRI could benefit from AI

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For a variety of reasons, functional and diffusion MRI haven’t been particularly…Read more on AuntMinnie.comRelated Reading:
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To ensure the continuity of high-quality HIV care in Kisumu County, Kenya during the corona virus disease 2019 pandemic, the Ministry of Health implemented a strategy to promote physical distancing and corona virus disease 2019 case detection. A total of 23 262 (84.2%) of the 27 641 patients eligible for early refill received an extra 3-month supply of antiretrovirals. Across 60 Ministry of Health clinics, average attendance decreased from 1298 to 640 patients per day postintervention, representing a 50.7% reduction.

Source: AIDSCategory: Infectious Diseases Tags: FAST TRACK Source Type: research

With current antiretroviral therapy, the lifespan of newly diagnosed persons with HIV (PWH) approaches that of uninfected persons. However, metabolic abnormalities related to both the disease and the virus itself, along with comorbidities of aging, have resulted in end-organ disease and organ failure as a major cause of morbidity and mortality. Solid organ transplantation is a life-saving therapy for PWH who have organ failure, and the approval of the HIV Organ Policy Equity Act has opened and expanded opportunities for PWH to donate and receive organs. The current environment of organ transplantation for PWH will be revie…

Source: AIDSCategory: Infectious Diseases Tags: EDITORIAL REVIEW Source Type: research

Conclusion:
Quantitative HIV-1 gp41 and gp160 antibody levels may serve as rapid, inexpensive screening tools for low PBMC HIV-1 DNA levels in children with viral suppression on ART, facilitating inclusion into remission protocols.

Source: AIDSCategory: Infectious Diseases Tags: BASIC SCIENCE Source Type: research

Conclusions:
This study provides a reproducible simple procedure for generating therapeutic grade iPSCs from HIV-infected patients and for engineering these cells to possess a naturally occurring genotype for resistance to HIV-1 infection when differentiated into immune cells.

Source: AIDSCategory: Infectious Diseases Tags: BASIC SCIENCE Source Type: research

Conclusion:
Our study demonstrates that iPSC—derived, gene—edited immune cells are resistant to distinct HIV—1 strains. These findings have important implications for both in-vitro stem cell development and therapeutic approaches to cure HIV infection.

Source: AIDSCategory: Infectious Diseases Tags: BASIC SCIENCE: CONCISE COMMUNICATION Source Type: research

Conclusion:
In this large cohort, DTG showed excellent virologic efficacy and was generally well tolerated. Whether DTG results in undesirable weight gain or rather statistically significant results, remains a debate.

Source: AIDSCategory: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research

Background:
Whilst reporting improved renal and bone safety profiles, studies have noted changes in lipid profiles among people living with HIV (PLWH) receiving antiretroviral therapy (ART) switching away from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF). We aimed to characterize changes in lipids observed after switching to TAF-containing ART in a real-world setting.
Methods:
A prospective study on PLWH enrolled in the UCD-ID Cohort study who switched to TAF-containing ART. Routine laboratory data [including lipids (total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein …

Source: AIDSCategory: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research

Conclusion:
PLWH treated with IMDs should be monitored carefully for virologic blips and incident infections. Checkpoint inhibitors may be associated with a higher rate of viral blips, although the clinical significance is unclear.

Source: AIDSCategory: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research

Conclusions:
Quarterly STI screening among MSM on PrEP could prevent a substantial number of partners from being exposed to asymptomatic STIs, and decrease transmission.

Source: AIDSCategory: Infectious Diseases Tags: CLINICAL SCIENCE: CONCISE COMMUNICATION Source Type: research

Conclusion:
These findings suggest that incident infections in rapidly growing clusters originate equally from diagnosed but unsuppressed cases and undiagnosed infections. These results highlight the importance of promoting retention in care and viral suppression as well as partner notification and other case-finding activities when investigating and intervening on high-priority molecular transmission clusters.

Source: AIDSCategory: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research

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