Functional nausea, gut, brain, or both?


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The gut-brain pathways for nausea, distinct from those for vomiting, .1 involve the convergence of the central and autonomic nervous system, endocrine, and gastrointestinal systems.2 Although vomiting is mediated through the brainstem and considered a motor response, nausea has sensory, cognitive, psychological, and homeostatic influences that trigger a response from the limbic system.3 The functional brain network for nausea is wide and the morphology of the subcortex (amygdala, caudate, and putamen) has been associated with the severity of nausea.

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