International study completes the largest genetic map of psychiatric disorders so far


(University of Barcelona) An international study published in the journal Cell, has described 109 genetic variants associated with eight psychiatric disorders: autism, ADHD, schizophrenia, bipolar disorder, depression, obsessive-compulsive disorder and Tourette Syndrome, in a total of about 230,000 patients worldwide.

Related Links:

CONCLUSIONS: Our findings suggest that future earnings of adolescents with depressive disorders are contingent on the duration and natural long-term course of early-onset depression, emphasising the need for timely and effective interventions to avoid loss of human capital.
PMID: 32345393 [PubMed – in process]

CONCLUSIONS: Shame in connection with sexual violence seems to play an important role in negative self-perception after rape. Dissociation not only plays an important role in unprocessed childhood trauma with feelings of shame, but also in more recent trauma experiences with shame.
PMID: 32345408 [PubMed – in process]

Hospice volunteers are a high-risk group for anxiety and depression owing to their frequent exposure to patients at the end of life and their subsequent deaths. Resilience is known to be a powerful factor that affects the occurrence of anxiety and depression; however, research on this subject is scarce. We investigated the relationship of resilience with anxiety or depression in hospice volunteers. A total of 145 volunteers were included in the analysis. Participants completed self-reported scales, including the Korean version of the Connor-Davidson Resilience Scale, the State-Trait Anxiety Inventory, Patient Health Questi…

Do children with autism spectrum disorders have a higher risk of obesity? What might be contributing risk factors for obesity in this population?Southern Medical Journal

Source: Medscape Today HeadlinesCategory: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

Conclusions: The present study detected arithmetic difficulties in Brazilian children with ADHD and the effects of methylphenidate. Given this improvement in sensitivity, combining tests could be a promising alternative when working with limited samples.Resumo Objetivo: Comparar as formas de avaliar as habilidades aritm éticas em crianças brasileiras com TDAH, combinando três testes neuropsicológicos validados, e verificar se são sensíveis ao tratamento com metilfenidato. Métodos: Quarenta e duas crianças (9 ‒ 12 anos) participaram deste estudo: 20 eram crian &ccedil…

Worry. Fear. Anxiety. Depression. As people grapple with sweeping changes, social isolation and concerns over health and work, it ’s clear that you don’t have to be infected with coronavirus disease 2019 (COVID-19) to feel its effects.

Employees can be especially vulnerable to the stress surrounding COVID-19. Their routines have been disrupted. Some find themselves working from home for the first time. Others are uncertai n about the risks of working with the public. These feelings can also be…

Contributors : Samantha Eck ; Song-Jun Xu ; Debra A BangasserSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusBackground: Stress exacerbates symptoms of schizophrenia and attention deficit hyperactivity disorder, which are characterized by impairments in sustained attention. Yet how stress regulates attention remains largely unexplored. Here we investigated whether a 6-day variable stressor (VS) altered sustained attention and the cholinergic attention system in male and female rats.Methods: Sustained attention was tested with the sustained attention task (SAT). Successful perform…

Source: GEO: Gene Expression OmnibusCategory: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research

Publication date: 12 December 2019Source: Cell, Volume 179, Issue 7Author(s): Cross-Disorder Group of the Psychiatric Genomics ConsortiumSummaryGenetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette synd…

Source: CellCategory: Cytology Source Type: research

, Eating Disorder Working Group of the PGC, Major Depressive Disorder Working Group of the PGC, Obsessive Compulsive Disorders and Tourette Syndrome Working Group of the PGC, Schizophrenia CLOZUK, Substance Use Disorder Working Group of the PGC, Agrawal A, Børglum AD, Bulik CM, Daly MJ, Davis LK, Demontis D, Edenberg HJ, Grove J, Gelernter J, Neale BM, Pardiñas AF, Stahl E, Walters JTR, Walters R, Sullivan PF, Posthuma D, Polderman TJC
PMID: 30334498 [PubMed – as supplied by publisher]

Source: Psychological MedicineCategory: Psychiatry Authors: Tags: Psychol Med Source Type: research

CONCLUSIONS: Given the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods. The findings also highlight large differences in genetic and environmental influences between psychiatric disorders, providing future directions for etiological psychiatric research.
PMID: 30221610 [PubMed – as supplied by publisher]

Source: Psychological MedicineCategory: Psychiatry Authors: Tags: Psychol Med Source Type: research

Source link


Please enter your comment!
Please enter your name here