Pregnancy Much More Likely for Teen Girls With ADHD

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WEDNESDAY, Oct. 2, 2019 — Girls with attention deficit hyperactivity disorder (ADHD) are six times more likely to wind up as teenage moms, a new Swedish study reports.
The impulsiveness and disorganization associated with ADHD appear to make girls…

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Abstract
Prenatal nicotine exposure (PNE) causes behavioral abnormalities in offspring, such as an enhancement of impulsivity and decrease in attention at adolescence. Here we examined the effects of galantamine (GAL) on the behavioral and electrophysiological changes induced by PNE in mice. Pregnant C57BL/6J mice were exposed to nicotine (0.2 mg/mL) dissolved in sweetened (2% saccharin) drinking water during gestational day 14 and perinatal day 0 (P0). At the ages of postnatal days 42-49 (P42-P49), female offspring displayed impulsivity in the cliff avoidance test and impairment of visual attention in the object-…

Source: Biochemical PharmacologyCategory: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research

We examined the association between prenatal antibiotic exposure and risk of ADHD.
METHODS: We conducted a population-based retrospective cohort study of children born in Manitoba, Canada, between 1998 and 2017 and their mothers. We defined exposure as the mother having filled 1 or more antibiotic prescriptions during pregnancy. The outcome was diagnosis of ADHD in the offspring, as identified in administrative databases. We estimated hazard ratios (HRs) using Cox proportional hazards regression in the overall cohort, in a separate cohort matched on high-dimensional propensity scores and in a sibling cohort.
RESULT…

In this issue Sucksdorff and colleagues1 present additional evidence of maternal health and nutrition during pregnancy affecting offspring mental health. In the Finnish National Registry, they identified 1,067 cases of attention-deficit/hyperactivity disorder (ADHD) and 1,067 matched controls. They found a highly significant negative association between maternal 25-hydroxyvitamin D (25(OH)D) levels the first half of pregnancy and later offspring diagnoses of ADHD. The lower the mother ’s vitamin D, the greater the risk of offspring ADHD, even after adjusting for maternal age and socioeconomic status (P=0.002).

Diabetes complicating pregnancy not only has serious effects on mothers, but also may affect the function of multiple systems in the fetus, especially the development of nervous system[1-3], which is attracting more and more attention and research. Results from studies showed this participates in the development of autism spectrum disorders (ASD)[4, 5], attention-deficit/hyperactivity disorder (ADHD)[6, 7], low verbal IQ[8, 9], poorer general cognitive function[10, 11], and language impariment[12].

Source: Diabetes Research and Clinical PracticeCategory: Endocrinology Authors: Tags: Review Source Type: research

Taking choline supplements during pregnancy may reduce the negative impact of viral respiratory infections on offspring, according to astudy published in theJournal of Psychiatric Research.“The new analysis may provide information relevant to potential COVID-19 effects on fetal brain development and their interaction with higher prenatal maternal choline levels,” wrote Robert Freedman, M.D., of the University of Colorado School of Medicine and colleagues.Previous studies showed that infection in pregnant women can affect fetal brain development and may increase the risk of attention-deficit/hyperactivity disord…

Source: Psychiatr NewsCategory: Psychiatry Tags: ADHD autism choline COVID-19 infant behavior Infant Behavior Questionnaire-Revised infections Journal of Psychiatric Research prenatal supplements Robert Freedman schizophrenia Source Type: research

Authors: Andrade C
Abstract
In observational studies, significant associations have often been identified between antidepressant drug prescription during pregnancy, on the one hand, and autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), on the other. Interpreting these associations is problematic because they are based on analyses that could not adjust for inadequately measured, unmeasured, and unknown confounds. Recent clinical data suggest that a genetic relationship exists between depression and neurodevelopmental disorders. A very recent study identified many genetic loci that w…

CONCLUSIONS: Reported associations between in utero exposure to antidepressants and physical, neurodevelopmental, and psychiatric outcomes, in large part, seem to be driven by the underlying maternal disorder. When limiting confounding by indication, prenatal exposure to antidepressants was significantly associated only with offspring BMI and affective disorders.
PMID: 32412703 [PubMed – as supplied by publisher]

ml;m AK
Abstract
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) affects 3-7% of women of childbearing age. Whether ADHD is associated with an increased risk of preterm birth is unclear.
DESIGN: National register-based cohort study.
SETTING: Sweden.
POPULATION: Nulliparous women giving birth to singleton infants 2007-2014 (n = 377,381).
METHODS: Women were considered to have ADHD if they had been dispensed at least one prescription for ADHD medication, i.e., a central nervous system stimulant or non-stimulant drugs for ADHD, prior to, during or after pregnancy (2005-2014). Women…

This study investigates the association between prenatal tetanus, diphtheria, acellular pertussis (Tdap) vaccination and attention deficit hyperactivity disorder (ADHD) risk in offspring. Retrospective cohort study of mother-child pairs born 1/1/2011-12/31/2014 at Kaiser Permanente Southern California. Tdap vaccination during pregnancy was obtained from electronic medical records. ADHD was defined by International Classification of Diseases, 9th/10th Revision codes and ADHD medications after age 3 years. Children were followed to first ADHD diagnosis, end of membership, or end of follow-up (12/31/2018). Cox proportional ha…

Source: Am J EpidemiolCategory: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research

ConclusionThe current evidence does not suggest that the use of ADHD medication during pregnancy results in significant adverse consequences for mother or offspring. However, the data are too limited to make an unequivocal recommendation. Therefore, physicians should consider whether the advantages of using ADHD medication outweigh the potential risks for the developing fetus according to each woman ’s specific circumstances. Future research should attempt to triangulate research findings based on a combination of different designs that differ in their underlying strengths and limitations and should investigate speci…

Source: CNS DrugsCategory: Neurology Source Type: research

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