Presentation of SARS-CoV-2 Infection As Cholestatic Jaundice in Two Healthy Adolescents


Liver abnormalities in severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection, including hepatitis and cholestasis, have been observed in adults and is associated with worse outcomes. We describe two adolescents with cholestasis and hepatitis with mild presentation of SARS-CoV-2 lacking typical symptoms. Our intention is to raise index of suspicion for testing and protective equipment use.

As of June 25, 2020, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) resulted in >9.4 million confirmed cases worldwide and > 482,000 deaths worldwide, including > 2.3 million cases and > 121,000 deaths reported in the US, among which were 84 pediatric deaths in persons , , )
In the United States, 22% of the population is comprised of infants, children, and adolescents

Coronavirus Disease 2019 in Children – United States, February 12-April 2, 2020.