Reply – The Journal of Pediatrics

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Di Mario et al raised concerns about our finding showing that acute rheumatic fever (ARF) develops in 49% of patients despite the antibiotic treatment and debate 1 potential explanation of these results. Because we documented that the mean duration of antibiotic treatment for primary prophylaxis was 5.9 ± 3.1 days, we speculated that the duration could partially explain the fact that ARF develops despite antibiotic treatment and, considering the incidence of ARF in our area, we suggested 10 days of antibiotic treatment, according to American Academy of Pediatrics1 and Infectious Disease Society of America.

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