Objective: Both qualitative and quantitative analyses were used to (a) describe the romantic and sexual relationships of adolescents with ADHD and (b) examine how ADHD-related impairments (e.g., social skill deficits and emotion dysregulation [ED]) …
Fragile X syndrome (FXS) was first clinically described in 1943 by Martin-Bell and in 1969 Lubs found a fragility at the terminal end of the X chromosome. In 1991, three different research groups independently cloned the mutation for the FMR1 gene (Fragile X mental retardation type 1) which has a CGG triplet expansion. The FMR1 gene codes for the FMR protein which is a major regulator of synaptic plasticity and is expressed in the brain and spermatogonia mainly but many other tissues during fetal and early neonatal development. The number of triplets and methylation correlates with clinical expression (increased…
CONCLUSION: Famous people with ADHD in this study revealed high skill levels in occupation, offering positive aspects of ADHD in adults.
PMID: 32321205 [PubMed – as supplied by publisher]
This study aimed to compare the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV) profiles of children with attention deficit/hyperactivity disorder (ADHD) and typically-developing children (TC) in Korea.
METHODS: The Korean version of the WISC-IV and the Advanced Test of Attention (ATA) were administered to 377 children and adolescents: 224 with ADHD (age 8.2±2.1 years, 182 boys) and 153 TC (age 8.7±2.4 years, 68 boys). Partial correlation and an analysis of covariance were used to investigate the relationship between the scores of the WISC-IV and the ATA.
RESULTS: The mean score of …
BACKGROUND: Fetal Alcohol Spectrum Disorder (FASD) is a diagnosis relating to neurocognitive impairments associated with prenatal alcohol exposure. A key aspect of improving FASD diagnostic processes and management is understanding the demographic and neurocognitive profile of those living with FASD. The aim of this study was to describe the demographic and neurocognitive profile of the first 199 individuals diagnosed with FASD in PATCHES Paediatrics clinics.
METHODS: A retrospective cross-sectional descriptive study design was conducted with individuals diagnosed with FASD between 2013 and 2018 thro…
ConclusionsASD and ADHD items loaded on separate components in our sample, suggesting that the measurement structure cannot explain the covariation between the two disorders in clinical samples. High levels of inattention and hyperactivity/impulsivity were seen in both ASD and ADHD in our clinical sample. This supports the need for a dimensional framework that examines neurodevelopmental domains across traditional diagnostic boundaries. Females also had lower component scores across social-communication, RRBI, and hyperactivity/impulsivity than males, suggesting that there may be gender-specific phenotypes related to the two conditions.
Publication date: Available online 23 April 2020Source: NeuroImage: ClinicalAuthor(s): Wenhao Jiang, Kuaikuai Duan, Kelly Rootes-Murdy, Pieter J. Hoekstra, Catharina A. Hartman, Jaap Oosterlaan, Dirk Heslenfeld, Barbara Franke, Jan Buitelaar, Alejandro Arias-Vasquez, Jingyu Liu, Jessica A. Turner
A 32-year-old child and adolescent psychiatry resident with a history of presenting an abstract at a local psychiatric conference during residency and fourth authorship on an immunotherapy paper from a summer internship during medical school presents with a new-onset desire to write a case report. She has just come off her consultation liaison rotation, during which she consulted on a 12-year-old boy with attention-deficit/hyperactivity disorder, oppositional defiant disorder, disruptive mood dysregulation disorder, and low depressive state hospitalized for pseudoseizures, a new-onset inability to walk, and aggressive outb…
Time for a new edition of SharpBrains’ e‑newsletter.
#1. First of all, it’s not all bad news this month. Study finds that moderate lifetime drinking may lead to lower Alzheimer-related beta amyloid deposits in the brain
#2. And, talk about personalized medicine! This fascinating study showing how brain imaging (fMRI) + machine learning + intensive, non-invasive neurostimulation = targeted treatments that can maximize efficacy and minimize side effects: Reinventing depression treatment via transcranial magnetic brain stimulation (TMS)
#3. Also, not a minute too soon … Meditation apps have gone m…
Publication date: Available online 22 April 2020Source: NeuroImage: ClinicalAuthor(s): Minchul Kim, Dohyun Kim, Sujin Bae, Doug Hyun Han, Bumseok Jeong
Publication date: July 2020Source: Research in Developmental Disabilities, Volume 102Author(s): Michal Al-Yagon, Michal Lachmi, Lilach Shalev