The genetic architecture of the human cerebral cortex


The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson’s disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.

Source: ScienceNOWCategory: Science Authors: Tags: Genetics, Online Only r-articles Source Type: news

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We reported a rare case of Ewing Sarcoma in a 62-year-old woman who had an unusual clinical presentation. She had right painless buttock swelling only for a month. Magnetic resonance imaging (MRI) revealed soft tissue sarcoma originated from right gluteal muscle. The diagnosis of Ewing sarcoma (ES) was made in a limited diagnostic material in an initial tru-cut biopsy, followed by an excision supported by immunohistochemistry (IHC) and Fluorescent In-Situ Hybridization (FISH).
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PMID: 32343155 [PubMed – as supplied by publisher]

Publication date: Available online 28 April 2020Source: Brain StimulationAuthor(s): Yosef A. Berlow, Amin Zandvakili, Noah S. Philip

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Source: Journal of Innovative Optical Health SciencesCategory: Biomedical Science Authors: Source Type: research

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PMID: 32340596 [PubMed – as supplied by publisher]

Source: Psychiatric ServicesCategory: Psychiatry Tags: Psychiatr Serv Source Type: research

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PMID: 32340595 [PubMed – as supplied by publisher]

Source: Psychiatric ServicesCategory: Psychiatry Tags: Psychiatr Serv Source Type: research

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PMID: 32340594 [PubMed – as supplied by publisher]

Source: Psychiatric ServicesCategory: Psychiatry Tags: Psychiatr Serv Source Type: research

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Source: Psychiatric ServicesCategory: Psychiatry Tags: Psychiatr Serv Source Type: research

This study reviews the discipline, models, and methodologies used to diagnose different psychological disorders. Initially, different types of human psychological disorders along with their biological and behavioural symptoms have been presented. The racial effects on these human disorders have been briefly explored. The morbidity rate of psychological disordered Indian patients has also been depicted. The significance of using different supervised learning and nature-inspired computing techniques in the diagnosis of different psychological disorders has been extensively examined and the publication trend of the related ar…

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