The genetic architecture of the human cerebral cortex

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The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson’s disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.

Source: ScienceNOWCategory: Science Authors: Tags: Genetics, Online Only r-articles Source Type: news

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PMID: 32343155 [PubMed – as supplied by publisher]

Publication date: Available online 28 April 2020Source: Brain StimulationAuthor(s): Yosef A. Berlow, Amin Zandvakili, Noah S. Philip

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Source: Journal of Innovative Optical Health SciencesCategory: Biomedical Science Authors: Source Type: research

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PMID: 32340596 [PubMed – as supplied by publisher]

Source: Psychiatric ServicesCategory: Psychiatry Tags: Psychiatr Serv Source Type: research

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Source: Psychiatric ServicesCategory: Psychiatry Tags: Psychiatr Serv Source Type: research

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PMID: 32340594 [PubMed – as supplied by publisher]

Source: Psychiatric ServicesCategory: Psychiatry Tags: Psychiatr Serv Source Type: research

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Source: Psychiatric ServicesCategory: Psychiatry Tags: Psychiatr Serv Source Type: research

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